Meyerson B A, Cui J G, Yakhnitsa V, Sollevi A, Segerdahl M, Stiller C O, O'Connor W T, Linderoth B
Department of Neurosurgery, Karolinska Institute/Hospital, Stockholm, Sweden.
Stereotact Funct Neurosurg. 1997;68(1-4 Pt 1):129-40. doi: 10.1159/000099914.
Experimental studies indicate that the effects of spinal cord stimulation (SCS) on 'hypersymptoms' in neuropathic pain conditions may at least partly be mediated via GABAergic and adenosine-dependent mechanisms. Concomitant intrathecal administration of receptor-active drugs modulating the function of the GABA and adenosine systems may both depress and enhance the effects of SCS. The first few patients with simultaneous intrathecal administration of the GABAB agonist baclofen and/or adenosine together with SCS, when the stimulation alone proved insufficient, are reported.
实验研究表明，脊髓刺激（SCS）对神经性疼痛状态下“高敏症状”的影响可能至少部分是通过γ-氨基丁酸（GABA）能和腺苷依赖性机制介导的。鞘内同时给予调节GABA和腺苷系统功能的受体活性药物，可能会抑制和增强SCS的效果。本文报告了最初几名在鞘内同时给予GABAB激动剂巴氯芬和/或腺苷并结合SCS治疗的患者，当时单独刺激证明效果不佳。
