Eide P K, Stubhaug A
Department of Neurosurgery, Ullevål Hospital, Oslo, Norway.
Stereotact Funct Neurosurg. 1997;68(1-4 Pt 1):207-11. doi: 10.1159/000099925.
We assessed thresholds for sensation of temperature and pressure and temporal summation of pain in the trigger area on the painful side and the contralateral nonpainful side in patients with trigeminal neuralgia previously treated with percutaneous retrogasserian glycerol rhizotomy (PRGR). Temperature and tactile thresholds were significantly increased on the painful side in both pain-free patients and patients with paroxysmal pain, but sensory loss was not more severe in patients with paroxysmal pain, except for increased warm thresholds. Abnormal temporal summation of pain (including progressive increase of pain intensity with radiation of pain and aftersensation) was present in the trigger area of patients with paroxysmal pain, but not in pain-free patients. Thus, relief of trigeminal neuralgia after PRGR involves normalization of abnormal temporal summation of pain, whereas sensory loss is less affected.
我们评估了先前接受经皮半月神经节甘油注射术(PRGR)治疗的三叉神经痛患者患侧触发区的温度觉、压力觉阈值以及疼痛的时间总和,并与对侧非疼痛侧进行了对比。无痛患者和阵发性疼痛患者的患侧温度觉和触觉阈值均显著升高,但除了温觉阈值升高外,阵发性疼痛患者的感觉丧失并不更严重。阵发性疼痛患者的触发区存在疼痛的异常时间总和(包括疼痛强度随疼痛放射和后感觉逐渐增加),而无痛患者则不存在。因此,PRGR术后三叉神经痛的缓解涉及疼痛异常时间总和的正常化,而感觉丧失受影响较小。