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羟氯喹肌病

Hydroxychloroquine myopathy.

作者信息

Richards A J

机构信息

Department of Rheumatology, Worthing Hospital, West Sussex, UK.

出版信息

J Rheumatol. 1998 Aug;25(8):1642-3.

PMID:9712114
Abstract

A woman with systemic lupus erythematosus developed severe myopathy after a septicemic episode, and her treatment before admission was hydroxychloroquine sulfate and prednisolone. A muscle biopsy revealed no evidence of vasculitis and creatine kinase was normal. She continued taking maintenance prednisolone and with intensive physiotherapy her muscle strength slowly returned. It is possible that the hydroxychloroquine was responsible for the myopathy.

摘要

一名患有系统性红斑狼疮的女性在发生败血症后出现了严重的肌病,入院前她接受的治疗药物是硫酸羟氯喹和泼尼松龙。肌肉活检未发现血管炎迹象,肌酸激酶水平正常。她继续服用维持剂量的泼尼松龙,并接受强化物理治疗,肌肉力量逐渐恢复。羟氯喹有可能是导致该肌病的原因。

相似文献

1
Hydroxychloroquine myopathy.羟氯喹肌病
J Rheumatol. 1998 Aug;25(8):1642-3.
2
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Relapsed hydroxychloroquine induced thrombocytopenia in a systemic lupus erythematosus patient.一名系统性红斑狼疮患者出现复发的羟氯喹诱导的血小板减少症。
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Evidence for risk of cardiomyopathy with hydroxychloroquine.羟氯喹啉致心肌病风险的证据。
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引用本文的文献

1
The toxic effects of chloroquine and hydroxychloroquine on skeletal muscle: a systematic review and meta-analysis.氯喹和羟氯喹对骨骼肌的毒性作用:系统评价和荟萃分析。
Sci Rep. 2021 Mar 23;11(1):6589. doi: 10.1038/s41598-021-86079-4.
2
Side Effects of Chloroquine and Hydroxychloroquine on Skeletal Muscle: a Narrative Review.氯喹和羟氯喹对骨骼肌的副作用:一项叙述性综述
Curr Pharmacol Rep. 2020;6(6):364-372. doi: 10.1007/s40495-020-00243-4. Epub 2020 Oct 31.
3
Ultrasonographic evaluation of the muscle architecture in patients with systemic lupus erythematosus.
超声评估系统性红斑狼疮患者的肌肉结构。
Clin Rheumatol. 2013 Aug;32(8):1155-60. doi: 10.1007/s10067-013-2249-8. Epub 2013 Apr 16.
4
Effect of competition bias in safety signal generation: analysis of a research database of spontaneous reports in France.竞争偏倚对信号产生的影响:法国自发报告研究数据库分析。
Drug Saf. 2012 Oct 1;35(10):855-64. doi: 10.1007/BF03261981.
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Antimalarial myopathy: an underdiagnosed complication? Prospective longitudinal study of 119 patients.抗疟药所致肌病:一种诊断不足的并发症?对119例患者的前瞻性纵向研究
Ann Rheum Dis. 2006 Mar;65(3):385-90. doi: 10.1136/ard.2004.023200. Epub 2005 Aug 11.
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Differential diagnosis of high serum creatine kinase levels in systemic lupus erythematosus.系统性红斑狼疮患者血清肌酸激酶水平升高的鉴别诊断
Rheumatol Int. 2003 Nov;23(6):319-23. doi: 10.1007/s00296-003-0309-0. Epub 2003 May 9.