单侧微量注射血管紧张素II至海马CA1区的不同行为效应。

Differential behavioral effects of angiotensin II microinjected unilaterally into the CA1 hippocampal area.

作者信息

Belcheva I, Chobanova M, Georgiev V

机构信息

Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia.

出版信息

Regul Pept. 1998 Jun 30;74(2-3):67-71. doi: 10.1016/s0167-0115(98)00015-9.

DOI:10.1016/s0167-0115(98)00015-9

PMID:9712165

Abstract

The behavioral responses of rats to unilateral microinjections of angiotensin II (ATII) into the left or right CA1 hippocampal area were studied. Unilateral (left or right) injections of ATII at a dose of 0.5 microg decreased locomotor activity but, at a dose of 1.0 microg, ATII increased it compared to the respective controls. The effect was more pronounced when ATII was microinjected into the left CAI hippocampal area. The elevated plus-maze experiments showed that ATII microinjections into the right CA1 hippocampal area at a dose of 0.5 microg decreased the ratio of the number of entries into the open arms to the total number of entries (into the open and closed arms). These findings suggest some asymmetric effects of ATII, depending on the dose, the behavioral test and the microinjected hemisphere.

摘要

研究了大鼠对向左侧或右侧海马CA1区单侧微量注射血管紧张素II（ATII）的行为反应。以0.5微克的剂量单侧（左侧或右侧）注射ATII会降低运动活性，但以1.0微克的剂量注射时，与各自的对照组相比，ATII会增加运动活性。当将ATII微量注射到左侧海马CA1区时，这种效应更为明显。高架十字迷宫实验表明，以0.5微克的剂量向右侧海马CA1区微量注射ATII会降低进入开放臂的次数与进入开放臂和封闭臂的总次数之比。这些发现表明，ATII的某些不对称效应取决于剂量、行为测试以及微量注射的半球。