Vilela M D, Siqueira W A, Rodriguez L D, Domingues S H, Rodrigues F D
G E N. 1977 Jan-Mar;31(3):149-55.
Patients with positive serum HBAg reactions were treated with Viramid (1-beta-D-ribofuranozyl-1, 2, 4-triazol-3-carboxamide) a new anti-viral drug. Of the patients involved in this study, 5 had chronic hepatitis or prolonged hepatitis and 12 were healthy HBAg carriers. Results obtained suggest that the drug had some action on serum HBAg titres with a decrease or negativation of HBAg serum titres in peripheric blood, the evaluation of which was immediately seen by employing the counterimmune electrophoresis technique.
血清HBAg反应呈阳性的患者用一种新型抗病毒药物Viramid(1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺)进行治疗。参与本研究的患者中,5例患有慢性肝炎或迁延性肝炎,12例为健康的HBAg携带者。所获得的结果表明,该药物对血清HBAg滴度有一定作用,可使外周血中HBAg血清滴度降低或转阴,采用对流免疫电泳技术可立即对其进行评估。