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[一种抗病毒药物对甲型肝炎病毒患者及健康携带者体内澳大利亚抗原的作用]

[Action of an anti-viral on the Australia antigen in patients with hepatitis A virus and in healthy carriers].

作者信息

Vilela M D, Siqueira W A, Rodriguez L D, Domingues S H, Rodrigues F D

出版信息

G E N. 1977 Jan-Mar;31(3):149-55.

PMID:97122
Abstract

Patients with positive serum HBAg reactions were treated with Viramid (1-beta-D-ribofuranozyl-1, 2, 4-triazol-3-carboxamide) a new anti-viral drug. Of the patients involved in this study, 5 had chronic hepatitis or prolonged hepatitis and 12 were healthy HBAg carriers. Results obtained suggest that the drug had some action on serum HBAg titres with a decrease or negativation of HBAg serum titres in peripheric blood, the evaluation of which was immediately seen by employing the counterimmune electrophoresis technique.

摘要

血清HBAg反应呈阳性的患者用一种新型抗病毒药物Viramid(1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺)进行治疗。参与本研究的患者中,5例患有慢性肝炎或迁延性肝炎,12例为健康的HBAg携带者。所获得的结果表明,该药物对血清HBAg滴度有一定作用,可使外周血中HBAg血清滴度降低或转阴,采用对流免疫电泳技术可立即对其进行评估。

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