Riantawan P, Punnotok J, Chaisuksuwan R, Pransujarit V
Central Chest Hospital, Department of Communicable Disease Control, Ministry of Public Health, Thailand.
Int J Tuberc Lung Dis. 1998 Aug;2(8):616-20.
To determine the proportion and profile of antituberculosis drug resistance among Mycobacterium tuberculosis isolates in Thailand.
A 500-bed cardiothoracic centre.
From January to December 1996, isolates of M. tuberculosis from consecutive patients with pulmonary tuberculosis underwent susceptibility testing to isoniazid (H), rifampicin (R), ethambutol (E), streptomycin (S), kanamycin (K), and ofloxacin (O).
In all, 1861 strains were tested, 1738 from new cases and 123 from previously treated cases. Overall initial and acquired resistance were 20.9% and 53.6%, respectively. The percentages of initial resistance to R, H, S, O, K and E were 12.6, 8.3, 6.6, 1.8, 1.1 and 0.8, respectively, whereas those of acquired resistance were 43.0, 29.2, 21.1, 9.7, 8.1 and 4.8, respectively. Multidrug resistance was observed in 4.2% of new patients and 25.2% of previously treated patients.
The overall drug resistance of M. tuberculosis in the central region of Thailand is high, and acquired multidrug resistance has reached an ominous level. The results have serious implications for tuberculosis control in Thailand. Urgent measures are needed to control the spread of drug resistance, and supervised treatment of standard protocol should be adhered to more strictly.
确定泰国结核分枝杆菌分离株中抗结核药物耐药性的比例和特征。
一家拥有500张床位的心胸中心。
1996年1月至12月，对连续的肺结核患者的结核分枝杆菌分离株进行了异烟肼（H）、利福平（R）、乙胺丁醇（E）、链霉素（S）、卡那霉素（K）和氧氟沙星（O）的药敏试验。
共检测了1861株菌株，其中1738株来自新发病例，123株来自既往治疗过的病例。总体初始耐药率和获得性耐药率分别为20.9%和53.6%。对R、H、S、O、K和E的初始耐药百分比分别为12.6%、8.3%、6.6%、1.8%、1.1%和0.8%，而获得性耐药百分比分别为43.0%、29.2%、21.1%...
