Kimura T, Goto K, Yabuki K, Mizuki N, Tamiya G, Sato M, Kimura M, Inoko H, Ohno S
Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Hum Immunol. 1998 Aug;59(8):500-2. doi: 10.1016/s0198-8859(98)00047-0.
Behçet's disease (BD) is known to be associated with HLA-B51. In order to investigate the influence of the MICB gene, located about 120 kb centromeric of the HLA-B gene, on the susceptibility to BD, (CA/TG) dinucleotide repeat microsatellite polymorphism in intron 1 of the MICB gene was investigated among 77 Japanese patients with BD, 60 randomly selected controls and 28 HLA-B51-positive unrelated healthy controls. There was no significant difference in the phenotype frequency of the microsatellite polymorphism between the BD patients and controls. This result suggests that the MICB gene itself is not responsible for the development of BD, and that the candidate gene(s) for BD is located between the MICA and HLA-C genes.
白塞病（BD）已知与HLA - B51相关。为了研究位于HLA - B基因着丝粒约120 kb处的MICB基因对BD易感性的影响，在77例日本BD患者、60例随机选择的对照以及28例HLA - B51阳性的无关健康对照中，研究了MICB基因内含子1中的（CA/TG）二核苷酸重复微卫星多态性。BD患者和对照之间微卫星多态性的表型频率没有显著差异。这一结果表明，MICB基因本身与BD的发生无关，并且BD的候选基因位于MICA和HLA - C基因之间。
