Mizuki N, Inoko H, Ohno S
Department of Ophthalmology, Yokohama City University School of Medicine, Kanagawa, Japan.
Int Rev Immunol. 1997;14(1):33-48. doi: 10.3109/08830189709116843.
HLA-B51 is well known to be associated with Behçet's disease (BD) in many different ethnic groups. The hypothesis may be presented that B51 molecules are primarily involved in BD development through specific antigen presentation. Furthermore, HLA-C genotyping by the polymerase chain reaction-sequence specific primers method suggests that the BD pathogenic gene is not the HLA-C gene itself but some other gene located near the HLA-B gene. Polymorphic analysis of the Tau-a microsatellite between the HLA-B and TNF genes indicates that the pathogenic gene of BD is not the HLA-B51 gene itself but other gene located around the HLA-B gene. Recent studies suggest that many novel genes exist in the region between the TNF and HLA-B or HLA-C genes such as MIC and PERB, etc. and furthermore, many unidentified new genes have been suggested to exist in this region. In this paper, the present situation of the investigations on the genetic predisposition responsible for BD was reviewed.
众所周知，在许多不同种族群体中，HLA - B51与白塞病（BD）相关。可能存在这样的假说：B51分子主要通过特定的抗原呈递参与BD的发展。此外，通过聚合酶链反应 - 序列特异性引物法进行的HLA - C基因分型表明，BD致病基因不是HLA - C基因本身，而是位于HLA - B基因附近的其他基因。对HLA - B和TNF基因之间的Tau - a微卫星进行多态性分析表明，BD致病基因不是HLA - B51基因本身，而是位于HLA - B基因周围的其他基因。最近的研究表明，在TNF和HLA - B或HLA - C基因之间的区域存在许多新基因，如MIC和PERB等，此外，还表明该区域存在许多未鉴定的新基因。本文综述了BD遗传易感性研究的现状。
