Linssen-Schuurmans C D, van Kan E J, Feith G W, Uges D R
Hospital Gelderse Vallei, Bennekom, Netherlands.
Ther Drug Monit. 1998 Aug;20(4):385-6. doi: 10.1097/00007691-199808000-00005.
The authors report toxicity caused by valacyclovir in a patient on hemodialysis. After initial recuperation resulting from treatment with hemodialysis, the patient experienced a relapse of neurologic symptoms, again necessitating hemodialysis. Although acyclovir and its analogues are generally safe drugs, they should be used with caution in patients with end-stage renal disease. Therapeutic drug monitoring may be indicated.
作者报告了一名接受血液透析的患者因服用伐昔洛韦而出现毒性反应。在通过血液透析治疗初步康复后，该患者神经症状复发，再次需要进行血液透析。尽管阿昔洛韦及其类似物通常是安全的药物，但在终末期肾病患者中应谨慎使用。可能需要进行治疗药物监测。
