Härtter S, Wetzel H, Hammes E, Torkzadeh M, Hiemke C
Department of Psychiatry, University of Mainz, Germany.
Ther Drug Monit. 1998 Aug;20(4):446-9. doi: 10.1097/00007691-199808000-00016.
This prospective study assessed fluvoxamine serum concentrations under two different fixed doses. The study included 15 male and female patients who met the DSM-III-R criteria for major depression. They were prescribed 50 mg fluvoxamine twice a day for 2 weeks and 100 mg twice a day thereafter. Drug monitoring was carried out on days 14 and 28. Fluvoxamine serum concentrations were highly variable between patients. After the dose was doubled, the serum concentrations of fluvoxamine increased disproportionately (mean, 3.4-fold), and there was a significantly (p < 0.05) more pronounced increase in men (4.6-fold) than in women (2.4-fold). These results provide evidence of nonlinear, sex-dependent pharmacokinetics of fluvoxamine.
这项前瞻性研究评估了两种不同固定剂量下氟伏沙明的血清浓度。该研究纳入了15名符合DSM-III-R重度抑郁症标准的男性和女性患者。他们先被开了每天两次、每次50毫克的氟伏沙明，服用2周，之后改为每天两次、每次100毫克。在第14天和第28天进行了药物监测。患者之间氟伏沙明的血清浓度差异很大。剂量加倍后，氟伏沙明的血清浓度不成比例地增加（平均为3.4倍），男性（4.6倍）的增加明显（p < 0.05）比女性（2.4倍）更显著。这些结果为氟伏沙明的非线性、性别依赖性药代动力学提供了证据。
