Kawano Y, Takaue Y, Watanabe T, Watanabe A, Iwai A, Kuroda Y
Department of Pediatrics, The University of Tokushima, Japan.
Bone Marrow Transplant. 1998 Jun;21 Suppl 3:S32-4.
The safety of injecting healthy donors with granulocyte colony-stimulating factor (G-CSF) has not been established. To evaluate PBSC mobilization and harvesting efficacy in the pediatric population, we compared it with those in adult donors. In this study, we conclude that PBSC mobilization and harvesting protocol in normal pediatric donors can be performed safely and effectively. Considering the lower frequency of side-effects and WBC counts, and G-CSF kinetics, higher dose of G-CSF would be recommended when small children become donors for adult patients.
向健康供体注射粒细胞集落刺激因子（G-CSF）的安全性尚未得到证实。为了评估儿科人群中外周血干细胞（PBSC）的动员和采集效果，我们将其与成年供体的情况进行了比较。在本研究中，我们得出结论，正常儿科供体的PBSC动员和采集方案可以安全有效地进行。考虑到副作用和白细胞计数的发生率较低以及G-CSF的动力学情况，当幼儿作为成年患者的供体时，建议使用更高剂量的G-CSF。
