性交后试验的有效性：随机对照试验。
Effectiveness of the postcoital test: randomised controlled trial.
作者信息
Oei S G, Helmerhorst F M, Bloemenkamp K W, Hollants F A, Meerpoel D E, Keirse M J
机构信息
Department of Obstetrics and Gynaecology, Saint Joseph Hospital, 5500 MB Veldhoven, Netherlands.
出版信息
BMJ. 1998 Aug 22;317(7157):502-5. doi: 10.1136/bmj.317.7157.502.
OBJECTIVES
To investigate the impact of the postcoital test on the pregnancy rate among subfertile couples and on the number of other diagnostic tests and treatments.
DESIGN
Randomised controlled study.
SETTING
A university and two non-university teaching hospitals in the Netherlands.
SUBJECTS
New couples at infertility clinics, 1 March 1993 to 1 October 1995; randomisation to an intervention group (series of infertility investigations that include the postcoital test) or to a control group (series excluding the test).
MAIN OUTCOME MEASURE
Cumulative pregnancy rate.
RESULTS
Of 736 consecutive new couples, 444 fulfilled the inclusion criteria and consented to participate (intervention group, 227; control group, 217). Treatment was given more often in the intervention group than in the control group (54% v 41%; difference 13% (95% confidence interval 4% to 22%)). Yet cumulative pregnancy rates at 24 months in the intervention group (49% (42% to 55%)) and the control group (48% (42% to 55%)) were closely similar (difference 1% (-9.0% to 9.0%)).
CONCLUSION
Routine use of the postcoital test in infertility investigations leads to more tests and treatments but has no significant effect on the pregnancy rate.
目的
探讨性交后试验对不育夫妇妊娠率以及其他诊断性检查和治疗次数的影响。
设计
随机对照研究。
地点
荷兰的一所大学医院和两所非大学教学医院。
研究对象
1993年3月1日至1995年10月1日期间不孕不育门诊的新夫妇；随机分为干预组（一系列包括性交后试验的不孕不育检查）和对照组（不包括该试验的一系列检查）。
主要观察指标
累积妊娠率。
结果
在736对连续的新夫妇中，444对符合纳入标准并同意参与研究（干预组227对，对照组217对）。干预组接受治疗的频率高于对照组（54%对41%；差异13%（95%置信区间4%至22%））。然而，干预组和对照组在24个月时的累积妊娠率相近（干预组49%（42%至55%），对照组48%（42%至55%）；差异1%（-9.0%至9.0%））。
结论
在不孕不育检查中常规使用性交后试验会导致更多的检查和治疗，但对妊娠率无显著影响。
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