饥饿选择可恢复铜绿假单胞菌群体感应突变体中弹性蛋白酶和鼠李糖脂的产生。
Starvation selection restores elastase and rhamnolipid production in a Pseudomonas aeruginosa quorum-sensing mutant.
作者信息
Van Delden C, Pesci E C, Pearson J P, Iglewski B H
机构信息
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
出版信息
Infect Immun. 1998 Sep;66(9):4499-502. doi: 10.1128/IAI.66.9.4499-4502.1998.
Abstract
The las quorum-sensing system of Pseudomonas aeruginosa controls the expression of elastase and rhamnolipid. We report that starvation can select a mutant producing these virulence factors in spite of a lasR deletion. Expression of the autoinducer synthase gene rhlI was increased in this suppressor mutant, suggesting compensation by the rhl system. These data show that P. aeruginosa can restore elastase and rhamnolipid production in the absence of a functional las quorum-sensing system.
摘要
铜绿假单胞菌的las群体感应系统控制弹性蛋白酶和鼠李糖脂的表达。我们报告称，尽管缺失lasR，饥饿仍可选择出产生这些毒力因子的突变体。在这种抑制突变体中，自诱导物合成酶基因rhlI的表达增加，提示由rhl系统进行补偿。这些数据表明，在缺乏功能性las群体感应系统的情况下，铜绿假单胞菌仍可恢复弹性蛋白酶和鼠李糖脂的产生。
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