MacLaren R E
Division of Ophthalmology, Royal Berkshire Hospital, Reading.
Br J Ophthalmol. 1998 May;82(5):577-83. doi: 10.1136/bjo.82.5.577.
Three separate experimental models of optic nerve regeneration have been presented--along the existing pathway in the presence of antibodies to neutralise inhibitory molecules, along peripheral nerve grafts and from retinal transplants. Each offers a theoretical clinical strategy for restoration of vision, if the mechanism of re-establishment of maps and reconnection to appropriate targets during regeneration can be determined. This is the process of axon guidance, and underlines the importance of our research into the molecular determinants that guide normal development of the visual system.
已经提出了三种不同的视神经再生实验模型——在存在中和抑制性分子的抗体的情况下沿现有路径再生、沿周围神经移植物再生以及通过视网膜移植再生。如果能够确定再生过程中图谱重建和与适当靶点重新连接的机制，那么每种模型都为恢复视力提供了一种理论上的临床策略。这就是轴突导向过程，突出了我们对指导视觉系统正常发育的分子决定因素进行研究的重要性。
