具有吡唑啉酮-5取代基的新型噻唑烷二酮-4作为潜在的非甾体抗炎药。
New thiazolidones-4 with pyrazolone-5 substituent as the potential NSAIDs.
作者信息
Lesyk R, Vladzimirska O, Zimenkovsky B, Horishny V, Nektegayev I, Solyanyk V, Vovk O
机构信息
Department of Pharmaceutical, Organic and Bioorganic Chemistry, State Medical University, Lviv, Ukraine.
出版信息
Boll Chim Farm. 1998 Jun;137(6):210-7.
The synthesis of a group of thiazolidine derivatives with pyrazolone-5 substituent is described. The structure of the new compounds is supported by 1H- and 13C-NMR spectra. Group of compounds was tested in vivo for their antiinflammatory activity. The obtained results gave the opportunity to separate the perspective groups of potential NSAIDs, which have got greater antiinflammatory activity than the best standard drugs.
描述了一组具有吡唑啉酮 -5 取代基的噻唑烷衍生物的合成。新化合物的结构由 1H - 和 13C - NMR 光谱证实。对该组化合物进行了体内抗炎活性测试。所得结果为分离出潜在的非甾体抗炎药（NSAIDs）的前景组提供了机会，这些前景组具有比最佳标准药物更强的抗炎活性。
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