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Condensed heterocyclic compounds: synthesis and antiinflammatory activity of novel thiazolo[3,2-alpha] pyrimidines.

作者信息

Tozkoparan B, Ertan M, Krebs B, Läge M, Kelicen P, Demirdamar R

机构信息

Hacettepe Univ., Faculty of Pharmacy, Dept. of Pharmaceutical Chemistry, Ankara, Turkey.

出版信息

Arch Pharm (Weinheim). 1998 Jun;331(6):201-6. doi: 10.1002/(sici)1521-4184(199806)331:6<201::aid-ardp201>3.0.co;2-t.

DOI:10.1002/(sici)1521-4184(199806)331:6<201::aid-ardp201>3.0.co;2-t
PMID:9713252
Abstract

In this study, thirty six new 2-benzylidene-7-methyl-3-oxo-5- phenyl-2,3-dihydro-5H-thiazolo[3,2-alpha]pyrimidine-6-carboxylic acid methyl esters were synthesized and characterized by spectral, crystallographic, and elemental analysis. The antiinflammatory activity of the compounds was tested by the carrageenan hind paw edema test. It was found that compound 6a having a 2-meth-oxyphenyl group at position 5 and a benzylidene group at position 2 was the most potent compound in this series. All the compounds that were tested for ulcer activity gave positive results.

摘要

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