Research on heterocyclic compounds. XXVIII. Imidazo[1,2-c]pyrimidines. - Suppr | 超能文献

Research on heterocyclic compounds. XXVIII. Imidazo[1,2-c]pyrimidines.

作者信息

Abignente E, Arena F, De Caprariis P, Luraschi E, Sacchi A, Lampa E, Berrino L, Donnoli D

机构信息

Dipartimento di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Università di Napoli Federico II.

出版信息

Farmaco. 1991 Oct;46(10):1099-110.

Abstract

A group of 24 imidazo[1,2-c]pyrimidines was taken into consideration in order to study their relationships between chemical structure and antiinflammatory activity. Some of these compounds were synthesized by us in the past, the others have been synthesized and characterized to complete the series. Antiinflammatory, analgesic, antipyretic and gastric ulcerogenic activities of such compounds were compared with those of indomethacin and discussed in terms of the effects exerted by the presence on the heterocyclic system of various substituents and an acidic or nonacidic moiety.

摘要

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