Hutchison S
University of Toronto, St Michael's Hospital, Ontario.
Can J Cardiol. 1998 Jul;14 Suppl D:20D-22D.
Figure 1 summarizes some of the current knowledge about the effects of tobacco smoke on the vasculature. Tobacco smoke changes the balance of vascular biology towards thrombosis by effects on platelets and on coagulation factors. It changes the balance of vascular tone from vasodilation to vasoconstriction, through both depression of vasodilatory pathways and augmentation of vasoconstrictor pathways. Tobacco smoke also changes a large group of as yet incompletely characterized influences (promoting proliferation, atherogenesis and the instability of lesions) that are responsible for the clinical activity of tobacco smoke-induced vascular disease.
图1总结了目前关于烟草烟雾对脉管系统影响的一些知识。烟草烟雾通过对血小板和凝血因子的作用，使血管生物学平衡朝着血栓形成方向改变。它通过抑制血管舒张途径和增强血管收缩途径，使血管张力平衡从血管舒张转向血管收缩。烟草烟雾还改变了一大类尚未完全明确的影响因素（促进增殖、动脉粥样硬化形成以及病变的不稳定性），这些因素导致了烟草烟雾诱导的血管疾病的临床活动。
