术前血清唾液酸化Lewis X-i抗原水平在非小细胞肺癌中的预测价值
Predictive value of preoperative serum sialyl Lewis X-i antigen levels in non-small cell lung cancer.
作者信息
Satoh H, Ishikawa H, Yamashita Y T, Takahashi H, Ishikawa S, Kamma H, Ohtsuka M, Hasegawa S
机构信息
Department of Respiratory Medicine, University of Tsukuba, Japan.
出版信息
Anticancer Res. 1998 Jul-Aug;18(4B):2865-8.
BACKGROUND AND STUDY OBJECTIVE
Serum sialyl Lewis X-i antigen has been shown to be one of the most specific markers for monitoring non-small cell lung cancer(NSCLC). We evaluated the correlation between serum levels of sialyl Lewis X-i antigen and mediastinal lymph node involvement in NSCLC patients.
METHODS
One hundred patients with untreated NSCLC were included in this study. All the patients received surgical treatment and the lymph nodes were evaluated pathologically. Pretreatment sera from these patients examined for the levels of sialyl Lewis X-i antigen, using a radioimmunoassay.
RESULTS
Serum levels of sialyl Lewis X-i antigen levels in patients with N2 were higher than those of N0-1(p = 0.0049). According to the receiver characteristic curve analysis, the recommended cut-off level of the antigen between N0-1 patients and N2 patients was 38.0 U/ml.
CONCLUSION
Measurement of serum levels of sialyl Lewis X-i antigen might provide preoperative information in patients with NSCLC.
背景与研究目的
血清唾液酸化刘易斯X-i抗原已被证明是监测非小细胞肺癌（NSCLC）最具特异性的标志物之一。我们评估了NSCLC患者血清唾液酸化刘易斯X-i抗原水平与纵隔淋巴结受累之间的相关性。
方法
本研究纳入100例未经治疗的NSCLC患者。所有患者均接受手术治疗，并对淋巴结进行病理评估。采用放射免疫分析法检测这些患者治疗前血清中唾液酸化刘易斯X-i抗原水平。
结果
N2期患者血清唾液酸化刘易斯X-i抗原水平高于N0-1期患者（p = 0.0049）。根据受试者特征曲线分析，N0-1期患者与N2期患者之间该抗原的推荐截断水平为38.0 U/ml。
结论
检测血清唾液酸化刘易斯X-i抗原水平可能为NSCLC患者提供术前信息。
Zotero 插件