Schneider J, Jimenez E, Marenbach K, Marx D, Meden H
Universidad del Pais Vasco, Facultad de Medicina, Departamento de Especialidades Medico-Quirurgicas, Leioa, Spain.
Anticancer Res. 1998 Jul-Aug;18(4C):2967-71.
Heat-shock proteins seem to play a still undefined role in cancer. One of them particularly, the low molecular weight HSP27, seems to be involved in resistance to chemotherapy. This phenomenon has been reported in breast cancer cell lines, and the aim of this study was to investigate if it also takes place in clinical tumour samples from ovarian cancer patients. We studied ovarian carcinoma samples from 95 patients by means of immunohistochemistry for the overexpression of both the product of the multidrug-resistance gene (P-glycoprotein) and HSP27. The expression of the MDR1 gene in more than 50% of the tumour cells was associated with an almost significantly shorter survival of patients with stage II, III and IV tumours (p = 0.05), although intriguingly not with the response to chemotherapy. Tumours expressing the MDR1 gene, furthermore, also tended to co-express HSP27 (64.9% vs. 42.1%), and this difference was statistically significant (p = 0.026).
热休克蛋白似乎在癌症中发挥着尚未明确的作用。其中一种特别的低分子量热休克蛋白27（HSP27）似乎与化疗耐药性有关。这种现象已在乳腺癌细胞系中得到报道，本研究的目的是调查它是否也发生在卵巢癌患者的临床肿瘤样本中。我们通过免疫组织化学研究了95例患者的卵巢癌样本，以检测多药耐药基因产物（P-糖蛋白）和HSP27的过表达情况。在超过50%的肿瘤细胞中MDR1基因的表达与II、III和IV期肿瘤患者的生存期几乎显著缩短相关（p = 0.05），尽管有趣的是与化疗反应无关。此外，表达MDR1基因的肿瘤也倾向于共表达HSP27（64.9%对42.1%），且这种差异具有统计学意义（p = 0.026）。
