吖啶衍生物对单纯疱疹病毒增殖的影响。

Effect of acridine derivatives on the multiplication of herpes simplex virus.

作者信息

Mucsi I, Molnár J, Tanaka M, Santelli-Rouvier C, Patelis A M, Galy J P, Barbe J

机构信息

Institute of Microbiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.

出版信息

Anticancer Res. 1998 Jul-Aug;18(4C):3011-5.

PMID:9713501

Abstract

The antiviral effect of 22 acridine derivatives was studied on the multiplication of herpes simplex virus type 2 (HSV-2) in Vero cells. The inhibitory effect of four acridine derivatives on the multiplication of HSV-2 is emphasised, six other compounds have moderate activity and three only slightly affect the virus multiplication, while nine compounds are inactive. Some of the effective derivatives inhibit the virus replication without any direct effect on the virus particles. However, the mechanism of the antiviral effect is still not known.

摘要

研究了22种吖啶衍生物对2型单纯疱疹病毒（HSV - 2）在非洲绿猴肾细胞（Vero细胞）中增殖的抗病毒作用。着重强调了四种吖啶衍生物对HSV - 2增殖的抑制作用，其他六种化合物具有中等活性，三种仅轻微影响病毒增殖，而九种化合物无活性。一些有效的衍生物抑制病毒复制，但对病毒颗粒没有任何直接影响。然而，抗病毒作用的机制仍然未知。