Albiol Matanic Vanesa C, Castilla Viviana
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, Piso 4, C1428BGA Buenos Aires, Argentina.
Int J Antimicrob Agents. 2004 Apr;23(4):382-9. doi: 10.1016/j.ijantimicag.2003.07.022.
The in vitro antiviral activity of antimicrobial cationic peptides: cecropin A, melittin, magainin I and II and indolicidin against the arenavirus Junin virus (JV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. Cecropin A effectively inhibited JV multiplication and failed to affect HSV replication whereas melittin impeded the multiplication of JV and HSV, but was highly toxic for the host cell. Magainins I and II exhibited inhibitory action toward HSV-1 and HSV-2 but were inactive against JV. Only indolicidin showed a direct inactivation effect on cell-free virus stocks. Besides its inhibitory effect on JV replication cecropin A also was active against the arenaviruses Tacaribe and Pichinde, mainly affecting late events of arenavirus multiplication cycle by preventing viral morphogenesis and egress from infected cells.
评估了抗菌阳离子肽天蚕素A、蜂毒肽、蛙皮素I和II以及吲哚杀菌素对沙粒病毒胡宁病毒（JV）、单纯疱疹病毒1型（HSV-1）和2型（HSV-2）的体外抗病毒活性。天蚕素A有效抑制JV增殖，对HSV复制无影响，而蜂毒肽阻碍JV和HSV增殖，但对宿主细胞毒性很大。蛙皮素I和II对HSV-1和HSV-2有抑制作用，但对JV无活性。只有吲哚杀菌素对无细胞病毒株有直接灭活作用。除了对JV复制有抑制作用外，天蚕素A对沙粒病毒塔卡里贝病毒和皮钦德病毒也有活性，主要通过阻止病毒形态发生和从感染细胞中释放来影响沙粒病毒增殖周期的后期事件。
