Link K R, Rand J S
Division of Companion Animal Clinical Sciences, School of Veterinary Science, University of Queensland, St Lucia, Brisbane, Australia.
J Am Vet Med Assoc. 1998 Aug 15;213(4):492-6.
To determine the reference range for glucose tolerance, using a simplified glucose tolerance test (GTT), and to evaluate glucose tolerance status in cats.
Prospective study.
57 clinically normal cats.
2 catheters were placed in the cephalic veins of nonsedated cats at least 3 hours before the test. Blood samples were obtained before (0 minutes) and 2, 5, 10, 15, 30, 45, 60, 90, and 120 minutes after glucose (0.5 g/kg [0.23 g/lb] of body weight) was injected i.v. Blood glucose concentration was measured by a glucose meter. Glucose half-life (t1/2) and disappearance of glucose (Kglucose) were calculated.
Glucose tolerance in cats was considered normal when upper limits for glucose concentration were < or = 159 mg/dl at 0 minutes, < or = 322 mg/dl at 60 minutes, < or = 238 mg/dl at 90 minutes, or < or = 171 mg/dl at 120 minutes and glucose t1/2 was < or = 94.7 minutes or Kglucose was > or = 0.41%/min. Impaired glucose tolerance in cats was defined as a glucose concentration > or = 160 mg/dl at 0 minutes, > or = 323 mg/dl at 60 minutes, > or = 239 mg/dl at 90 minutes, or > or = 172 mg/dl at 120 minutes. The frequency of impaired glucose tolerance was 2%. Five cats had stress-affected GTT. Significant differences in glucose t1/2 or Kglucose between cats < 7 and > or = 7 years old were not found.
The simplified GTT and measurement of glucose concentration by a glucose meter provides a simple and low-cost method of assessing glucose tolerance status in cats that are normoglycemic after food is withheld. Use of absolute glucose concentrations overcomes the need to calculate glucose t1/2 values. The high glucose concentration at 0 minutes found in this study may reflect a more realistic concentration to use in assessing client-owned cats in a hospital environment.
使用简化葡萄糖耐量试验（GTT）确定猫的葡萄糖耐量参考范围，并评估猫的葡萄糖耐量状态。
前瞻性研究。
57只临床正常的猫。
在试验前至少3小时，将2根导管置于未镇静猫的头静脉中。静脉注射葡萄糖（0.5 g/kg[0.23 g/lb体重]）前（0分钟）以及注射后2、5、10、15、30、45、60、90和120分钟采集血样。用血糖仪测量血糖浓度。计算葡萄糖半衰期（t1/2）和葡萄糖消失率（K葡萄糖）。
当葡萄糖浓度上限在0分钟时≤159 mg/dl、60分钟时≤322 mg/dl、90分钟时≤238 mg/dl或120分钟时≤171 mg/dl，且葡萄糖t1/2≤94.7分钟或K葡萄糖≥0.41%/分钟时，猫的葡萄糖耐量被认为正常。猫的葡萄糖耐量受损定义为0分钟时葡萄糖浓度≥160 mg/dl、60分钟时≥323 mg/dl、90分钟时≥239 mg/dl或120分钟时≥172 mg/dl。葡萄糖耐量受损的频率为2%。5只猫的GTT受应激影响。未发现7岁以下和7岁及以上猫之间在葡萄糖t1/2或K葡萄糖方面存在显著差异。
简化的GTT和用血糖仪测量葡萄糖浓度为评估禁食后血糖正常的猫的葡萄糖耐量状态提供了一种简单且低成本的方法。使用绝对葡萄糖浓度无需计算葡萄糖t1/2值。本研究中在0分钟时发现的高葡萄糖浓度可能反映了在医院环境中评估家养猫时使用的更实际的浓度。
