Link Karl R, Rand Jacquie S
Centre for Companion Animal Health, School of Veterinary Science, University of Queensland, Queensland 4072, Australia.
J Feline Med Surg. 2008 Dec;10(6):583-92. doi: 10.1016/j.jfms.2008.08.005. Epub 2008 Nov 6.
The aim of the study was to determine the time required for plasma fructosamine concentration to increase after the onset of hyperglycaemia and decrease after resolution of hyperglycaemia. Healthy cats (n=14) were infused to maintain either moderate hyperglycaemia (n=5) (actual mean glucose 17 mmol/l) or marked hyperglycaemia (n=9) (actual 29 mmol/l) for 42 days. Fructosamine exceeded the upper limit of the reference range (331 micromol/l) after 3-5 days of marked hyperglycaemia, took 20 days to plateau and, after cessation of infusion, took 5 days to return to baseline. Fructosamine concentration for moderate hyperglycaemia took longer to exceed the reference range (7 days, range 4-14 days), and fewer days to plateau (8 days) and return to baseline (1 day). In cats with moderate hyperglycaemia, fructosamine concentration mostly fluctuated under the upper limit of the reference range. The range of fructosamine concentrations associated with a given glucose concentration was wide. The critical difference for fructosamine was 33 micromol/l.
该研究的目的是确定高血糖发作后血浆果糖胺浓度升高以及高血糖消退后降低所需的时间。对14只健康猫进行输注，以维持42天的中度高血糖（n = 5）（实际平均血糖17 mmol/l）或显著高血糖（n = 9）（实际29 mmol/l）。在显著高血糖3 - 5天后，果糖胺超过参考范围上限（331 μmol/l），20天达到平稳状态，停止输注后，5天恢复至基线水平。中度高血糖时果糖胺浓度超过参考范围所需时间更长（7天，范围4 - 14天），达到平稳状态（8天）和恢复至基线水平（1天）所需天数更少。在中度高血糖的猫中，果糖胺浓度大多在参考范围上限以下波动。与给定血糖浓度相关的果糖胺浓度范围很宽。果糖胺的临界差值为33 μmol/l。
