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[牙菌斑是幽门螺杆菌的正常储存库吗?]

[Is dental plaque a normal Helicobacter pylori reservoir?].

作者信息

Améndola R, Roldán C D, Morgade L, Solagna A, Lineado A, Musi A O, Valero J, Zerbo O, Kogan Z, Ferro F E, Schenone L, Corti R

机构信息

Sección esófago y estómago, Hospital de Gastroenterología B. Udaondo.

出版信息

Acta Gastroenterol Latinoam. 1998;28(2):199-201.

PMID:9713656
Abstract

The mechanisms of transmission and reservoir of Helicobacter pylori is still unclear; even it has been suggested that dental plaque could be the bacterial reservoir and one important factor in the reinfection. The aim of the study was to evaluate the prevalence of Helicobacter pylori in dental plaque in 20 patients with non ulcer dyspepsia (12 females, 7 males; mean age 40.5 years) and antral infection; and to establish the presence of bacteria in dental plaque and gastric mucosa after eradication. Gastric colonization in all of them was confirmed by five samples (three of antrum and two of body) with Giemsa conventional technique, clotest and culture. When clotest was positive in gastric mucosa, we performed the scrape of dental plaque and sending the material for culture. All patients were treated with a scheme of seven days with one protom pump inhibitor and two antibiotics. After four weeks all the patients were controlled with endoscopy and culture of dental plaque to confirm eradication. Dental plaque culture was positive in 1/20 patients (5%), and this results was similar to developed countries, using as detection method culture or polymerase chain reaction (PCR).

摘要

幽门螺杆菌的传播机制和储存库仍不清楚;甚至有人提出牙菌斑可能是细菌储存库,也是再次感染的一个重要因素。本研究的目的是评估20例非溃疡性消化不良患者(12名女性,7名男性;平均年龄40.5岁)牙菌斑中幽门螺杆菌的患病率以及胃窦感染情况;并确定根除后牙菌斑和胃黏膜中细菌的存在情况。通过吉姆萨传统技术、尿素酶试验和培养,对所有患者的五个样本(三个胃窦样本和两个胃体样本)进行检测,以确认胃内定植情况。当胃黏膜尿素酶试验呈阳性时,我们刮取牙菌斑并送检培养。所有患者均接受了为期七天的质子泵抑制剂和两种抗生素的治疗方案。四周后,所有患者均接受内镜检查和牙菌斑培养,以确认根除情况。牙菌斑培养在1/20患者(5%)中呈阳性,这一结果与发达国家相似,采用培养或聚合酶链反应(PCR)作为检测方法。

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