Xu J, Sotereanos D G, Moller A R, Jacobsohn J, Tomaino M M, Fischer K J, Herndon J H
Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania, USA.
J Reconstr Microsurg. 1998 Jul;14(5):323-8; discussion 329-30. doi: 10.1055/s-2007-1000185.
The surgical outcome in recurrent chronic nerve compression remains unsatisfactory. Clinically, it has been reported that vein grafts can be used to wrap the nerve, following nerve decompression, to improve the functional recovery of the nerve. In order to determine the safety and feasibility of the technique of vein wrapping of nerve, this study assessed the effect of vein-graft wrapping around normal nerve. In each of 30 rats, a segment of femoral vein was wrapped around the sciatic nerve. Functional, electrophysiologic, and histologic testing was performed at 9, 12 and 15 weeks postoperatively, and the results showed no significant differences between the experimental and control groups. Neither scar tissue between the nerve and the vein graft, nor demyelinization or degeneration of the nerve fibers were identified histologically. The study demonstrated that autogenous vein-graft wrapping did not result in any pathologic nerve entrapment. The technique of vein wrapping of nerve appears to be safe, feasible, and reliable. The results supported further study for the use of vein-graft wrapping in the surgical management of recurrent chronic nerve compression.
复发性慢性神经压迫的手术效果仍不尽人意。临床上，有报道称在神经减压后可使用静脉移植物包裹神经，以改善神经的功能恢复。为了确定神经静脉包裹技术的安全性和可行性，本研究评估了静脉移植物包裹正常神经的效果。在30只大鼠中，每只大鼠均用一段股静脉包裹坐骨神经。术后9周、12周和15周进行功能、电生理和组织学检测，结果显示实验组和对照组之间无显著差异。组织学检查未发现神经与静脉移植物之间有瘢痕组织，也未发现神经纤维脱髓鞘或变性。该研究表明自体静脉移植物包裹不会导致任何病理性神经卡压。神经静脉包裹技术似乎是安全、可行且可靠的。这些结果支持进一步研究静脉移植物包裹在复发性慢性神经压迫手术治疗中的应用。
