The effect of furosemide on the renal damage induced by toxic mushroom Cortinarius speciosissimus in the rat.

The effect of furosemide on the renal damage induced by the toxic mushroom Cortinarius speciosissimus was studied in female rats. Furosemide (50 mg/kg s.c.) was given 15 min before the mushroom administration (250 mg dried mushroom/kg body weight p.o.). It was observed that furosemide clearly increased the tubular damage induced by C. speciosissimus. In contrast, furosemide had no effect on the inflammation induced by this toxic mushroom.