El Azami El Idrissi M, Mazza G, Monteyne P, Elson C J, Day M J, Pfau C J, Coutelier J P
Unit of Experimental Medicine, International Institute for Cellular Pathology, Université Catholique de Louvain, Bruxelles, Belgium.
Proc Soc Exp Biol Med. 1998 Sep;218(4):349-56. doi: 10.3181/00379727-218-44303.
The effect of LCMV on CD4+ T lymphocytes was analyzed in C3HeB/FeJ mice after infection with the Docile strain of this virus. Our results indicated that LCMV triggers: i) an inhibition of Th2 lymphocyte differentiation induced by concomitant immunization with a nonviral protein antigen; ii) a depression of T helper-dependent antibody responses elicited by such an immunization; and iii) a CD4+ cell-mediated proliferation of spleen cells leading to increased interleukin-4 and interferon-gamma message expression and IgG2a-restricted total immunoglobulin secretion. Taken together, these results indicate that LCMV profoundly affects CD4+ cell-mediated immune responses in infected animals. Such modulations of T-helper functions may explain the preponderance of IgG2a in the antierythrocyte autoimmune response induced by the virus in C3HeB/FeJ mice.
在用该病毒的温顺株感染C3HeB/FeJ小鼠后，分析了淋巴细胞脉络丛脑膜炎病毒（LCMV）对CD4+ T淋巴细胞的影响。我们的结果表明，LCMV引发：i）由非病毒蛋白抗原伴随免疫诱导的Th2淋巴细胞分化的抑制；ii）这种免疫引发的T辅助细胞依赖性抗体反应的抑制；以及iii）脾细胞的CD4+细胞介导的增殖，导致白细胞介素-4和干扰素-γ信使表达增加以及IgG2a限制性总免疫球蛋白分泌增加。综上所述，这些结果表明LCMV深刻影响受感染动物中CD4+细胞介导的免疫反应。T辅助功能的这种调节可能解释了在C3HeB/FeJ小鼠中由该病毒诱导的抗红细胞自身免疫反应中IgG2a占优势的原因。
