槲皮素增强大鼠胰腺癌发生的NMU模型中的癌前病变。

Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis.

作者信息

Barotto N N, López C B, Eynard A R, Fernández Zapico M E, Valentich M A

机构信息

Ilda. Cátedra de Histología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.

出版信息

Cancer Lett. 1998 Jul 3;129(1):1-6. doi: 10.1016/s0304-3835(98)00033-0.

DOI:10.1016/s0304-3835(98)00033-0

PMID:9714328

Abstract

The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.

摘要

在接受亚硝基甲基脲（NMU）治疗的大鼠中评估了膳食槲皮素（Q）的作用。在接受NMU（87%）和Q-NMU（100%）治疗的组中观察到胰腺结节和局灶性腺泡细胞增生。虽然在NMU治疗组中发现有发育异常灶的大鼠占27%，但Q-NMU治疗导致有发育异常灶的大鼠数量显著更高（73%）。此外，在这些动物中发现了原位癌（12%）和1例微癌（4%）。在Q-NMU组的局灶性腺泡细胞增生中，有丝分裂显著增加，细胞凋亡减少。我们目前的结果支持槲皮素在大鼠胰腺癌发生的NMU模型中具有促进和进展作用。