Ergenoglu T, Demiralp T, Beydagi H, Karamürsel S, Devrim M, Ermutlu N
Department of Physiology, Gaziantep University, Medical Faculty, Turkey.
Neurosci Lett. 1998 Jul 17;251(1):61-4. doi: 10.1016/s0304-3940(98)00498-4.
Effects of the spontaneous slow cortical potential (SCP) shifts of the electroencephalogram (EEG) on the P300 response were investigated on ten healthy volunteers. P300 responses were recorded using an auditory oddball paradigm, where target stimuli were presented regularly after every four standard stimuli. Single event-related potential (ERP) sweeps exhibiting negative or positive SCP shifts were averaged separately. The P300 amplitude was significantly larger during negative SCP shifts. Furthermore, the topographies of P200 and P300 waves obtained during negative and positive SCP shifts showed significant differences. The results indicate that the SCP shifts in single ERP sweeps, which are considered to be correlated with the arousal or basic activity level of the cortex, explain at least part of the inter-trial variability of P300 response.
在十名健康志愿者身上研究了脑电图（EEG）自发慢皮层电位（SCP）变化对P300反应的影响。使用听觉oddball范式记录P300反应，在每四个标准刺激后定期呈现目标刺激。分别对显示负向或正向SCP变化的单个事件相关电位（ERP）扫描进行平均。在负向SCP变化期间，P300波幅显著更大。此外，在负向和正向SCP变化期间获得的P200和P300波的地形图显示出显著差异。结果表明，单个ERP扫描中的SCP变化被认为与皮层的唤醒或基本活动水平相关，这至少解释了P300反应试验间变异性的部分原因。
