Sumich Alex, Kumari Veena, Dodd Phillipa, Ettinger Ulrich, Hughes Catherine, Zachariah Elizabeth, Sharma Tonmoy
King's College London, Institute of Psychiatry, BIAU, Centre for Neuroimaging Sciences, London SE5 8AF, UK.
Schizophr Res. 2008 Jan;98(1-3):265-77. doi: 10.1016/j.schres.2007.09.018. Epub 2007 Nov 19.
P300 amplitude reduction is reliably seen in schizophrenia. Inconsistent reports of isolated frontal and/or parietal deficits in unaffected family members may be clarified using a task that places greater load on frontal function.
Go and No-Go versions of the auditory oddball task were performed by eighteen schizophrenia patients, age-matched unaffected siblings and healthy controls matched closely to unaffected siblings on age, sex, education, socioeconomic-status, handedness and ethnicity. Groups were compared on P300 and N100 amplitude and latency. Spearman correlations were used to test the relationship between ERP amplitudes and neuropsychological measures of executive function and memory. The relationship between schizotypy--as measured using the structured interview--and ERPs was explored in a combined group of siblings and controls.
Independent of task, patients had lower P300 than controls and reduced parietal amplitude compared to siblings. Siblings had enhanced frontocentral N100 compared to controls. No-Go P300 amplitude and N100 latency was associated with executive function measures. There were significant intraclass correlations between patients and siblings for No-Go P300 amplitude, particularly at the central midline electrode. Frontocentral N100 and P300 amplitude were positively correlated with anxiety-related aspects of schizotypy.
Enhanced N100 is present in unaffected siblings. Parietal P300 is intact in unaffected siblings, but reduced in patients. The No-Go-oddball is more sensitive than the Go-oddball to executive function deficits in patients and as an index of heritability.
精神分裂症患者中可可靠观察到P300波幅降低。对于未患病家庭成员中孤立的额叶和/或顶叶功能缺陷的报告不一致，可通过一项对额叶功能施加更大负荷的任务来加以阐明。
对18名精神分裂症患者、年龄匹配的未患病同胞以及在年龄、性别、教育程度、社会经济地位、利手和种族方面与未患病同胞紧密匹配的健康对照者进行听觉Oddball任务的“是”和“否”版本测试。比较各组的P300和N100波幅及潜伏期。采用斯皮尔曼相关性分析来检验ERP波幅与执行功能和记忆的神经心理学测量指标之间的关系。在同胞和对照者的合并组中探讨使用结构化访谈测量的精神分裂症型人格与ERP之间的关系。
与任务无关，患者的P300波幅低于对照者，且与同胞相比顶叶波幅降低。同胞与对照者相比额中央N100增强。“否”任务的P300波幅和N100潜伏期与执行功能测量指标相关。“否”任务的P300波幅在患者和同胞之间存在显著的组内相关性，尤其是在中央中线电极处。额中央N100和P300波幅与精神分裂症型人格的焦虑相关方面呈正相关。
未患病同胞存在增强的N100。未患病同胞的顶叶P300是完整的，但患者中降低。“否”Oddball任务比“是”Oddball任务对患者的执行功能缺陷更敏感，并且可作为遗传度的指标。
