Novel HLA-A and HLA-B alleles.

作者信息

Hurley C K, Steiner N, Kosman C, Mitton W, Koester R, Bei M, Bush J, McCormack J, Hahn A, Henson V, Hoyer R, Wade J A, Hartzman R J, Ng J

机构信息

Department of Microbiology and Immunology, Georgetown University Medical School, Washington, DC, USA.

出版信息

Tissue Antigens. 1998 Jul;52(1):84-7. doi: 10.1111/j.1399-0039.1998.tb03029.x.

DOI:10.1111/j.1399-0039.1998.tb03029.x

PMID:9714480

Abstract

Nine novel HLA-A and HLA-B alleles are described: A2609, A6803, A6806, B1539, B1540, B2712, B4103, B5109, and B5603. Most appear to have arisen by gene conversion events. B5603 appears to have arisen by a reciprocal recombination event joining exon 2 of a B55/ 56 allele with exon 3 of a B15 allele. Serologically, the antigen encoded by this allele types with broad B22- and Bw6-specific alloantisera. Also unique, the antigen encoded by B2712 does not react with B27-specific alloantisera but does react with Bw6-specific alloantisera.

摘要