内源性血小板生成素水平对原发性血小板增多症和反应性血小板增多症鉴别诊断的影响。

Impact of endogenous thrombopoietin levels on the differential diagnosis of essential thrombocythaemia and reactive thrombocytosis.

作者信息

Hou M, Carneskog J, Mellqvist U H, Stockelberg D, Hedberg M, Wadenvik H, Kutti J

机构信息

Department of Medicine, Sahlgrenska University Hospital, Göteborg University, Sweden.

出版信息

Eur J Haematol. 1998 Aug;61(2):119-22. doi: 10.1111/j.1600-0609.1998.tb01071.x.

DOI:10.1111/j.1600-0609.1998.tb01071.x

PMID:9714524

Abstract

By using the newly commercialized Quantikine human TPO immunoassay, plasma thrombopoietin (TPO) concentrations were measured in 12 patients with essential thrombocythaemia (ET), 13 patients with reactive thrombocytosis (RT) and 11 healthy volunteers. For the healthy volunteers the mean plasma TPO concentration was 21.1+/-11.0 pg/ml. The mean plasma TPO concentration in the group of RT was slightly lower (16.4+/-8.6 pg/ml) but did not differ significantly from the control group. The mean plasma TPO concentration in ET patients (44.1+/-45.2 pg/ml) was significantly (p<0.05) higher than the mean for RT patients, but did not differ statistically from the mean of healthy volunteers. These data suggest a defective clearance of plasma TPO in patients with ET.

摘要

通过使用新商业化的Quantikine人血小板生成素免疫测定法，对12例原发性血小板增多症（ET）患者、13例反应性血小板增多症（RT）患者和11名健康志愿者的血浆血小板生成素（TPO）浓度进行了测量。对于健康志愿者，血浆TPO平均浓度为21.1±11.0 pg/ml。RT组的血浆TPO平均浓度略低（16.4±8.6 pg/ml），但与对照组无显著差异。ET患者的血浆TPO平均浓度（44.1±45.2 pg/ml）显著高于RT患者（p<0.05），但与健康志愿者的平均值无统计学差异。这些数据表明ET患者血浆TPO清除存在缺陷。