Oda S, Hirasawa H, Sugai T, Shiga H, Matsuda K, Ueno H
Department of Emergency and Critical Care Medicine, Chiba University School of Medicine, Japan.
J Trauma. 1998 Aug;45(2):304-10; discussion 310-1. doi: 10.1097/00005373-199808000-00016.
Cellular Injury Score (CIS) is an index of cellular injury, being calculated from three parameters of intracellular metabolism: arterial ketone body ratio, osmolality gap, and blood lactate.
The usefulness of CIS as a severity scoring system for patients with multiple organ failure was prospectively evaluated in 157 consecutive patients with MOF (58 survivors, 99 nonsurvivors).
CISs in nonsurvivors were significantly higher compared with those in survivors throughout the clinical courses. CIS was significantly correlated with the number of failing organs and mortality rate. The optimal cutoff point of CIS from receiver operating characteristics curve analysis was 4 for the maximal value during the clinical course. The changes in CIS well reflected the severity of injury in survivors and nonsurvivors who died within 2 weeks.
CIS could be a useful index for mortality risk prediction and is potentially applicable as a severity scoring system for individual patients with MOF.
细胞损伤评分（CIS）是一种细胞损伤指标，由细胞内代谢的三个参数计算得出：动脉酮体比率、渗透压间隙和血乳酸。
前瞻性评估157例连续的多器官功能衰竭患者（58例存活者，99例非存活者）中CIS作为严重程度评分系统的实用性。
在整个临床过程中，非存活者的CIS显著高于存活者。CIS与衰竭器官数量和死亡率显著相关。根据受试者工作特征曲线分析，临床过程中CIS的最佳截断值为4（最大值）。CIS的变化很好地反映了存活者和2周内死亡的非存活者的损伤严重程度。
CIS可能是预测死亡风险的有用指标，并有可能作为个体多器官功能衰竭患者的严重程度评分系统。
