阿拉巴马州杰斐逊县卡立普多致死案例综述。
A review of carisoprodol deaths in Jefferson County, Alabama.
作者信息
Davis G G, Alexander C B
机构信息
Department of Pathology, University of Alabama at Birmingham, USA.
出版信息
South Med J. 1998 Aug;91(8):726-30. doi: 10.1097/00007611-199808000-00004.
BACKGROUND
Carisoprodol is a skeletal muscle relaxant with the potential for abuse. A carisoprodol overdose is rarely considered fatal. Nevertheless, we encountered carisoprodol in several cases, prompting review of our experience.
METHODS
We did a retrospective study of cases examined at the Jefferson County Coroner/Medical Examiner Office from January 1, 1986, to October 31, 1997, reviewing investigative reports and autopsy findings.
RESULTS
Carisoprodol was present in 24 cases. Seventeen decedents died of acute drug intoxication. Carisoprodol was never the sole drug detected at autopsy, nor was it ever the sole cause of death. Propoxyphene was a co-intoxicant in 8 of the 24 cases.
CONCLUSIONS
Carisoprodol causes respiratory depression. Since the mechanism of death was respiratory depression in 82% of the decedents who died of acute intoxication, we consider that carisoprodol was probably responsible, in part, for those deaths. The simultaneous use of propoxyphene and carisoprodol seems to be especially dangerous.
背景
卡立普多是一种具有滥用潜力的骨骼肌松弛剂。卡立普多过量服用很少被认为会致命。然而，我们在几起病例中发现了卡立普多，促使我们对自身经验进行回顾。
方法
我们对1986年1月1日至1997年10月31日在杰斐逊县验尸官/法医办公室检查的病例进行了回顾性研究，查阅了调查报告和尸检结果。
结果
24例病例中检测到卡立普多。17名死者死于急性药物中毒。卡立普多从未在尸检时被检测为唯一药物，也从未是唯一死因。在24例病例中的8例中，丙氧芬是共同中毒药物。
结论
卡立普多会导致呼吸抑制。由于在死于急性中毒的死者中，82%的死亡机制是呼吸抑制，我们认为卡立普多可能在一定程度上导致了这些死亡。同时使用丙氧芬和卡立普多似乎特别危险。
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