Harrop J S, Davies T J, Capra L G, Marks V
Clin Endocrinol (Oxf). 1976 Jul;5(4):313-21. doi: 10.1111/j.1365-2265.1976.tb01960.x.
Hypothalamic-pituitary function was examined in seventeen patients treated in the past for extrasellar intracranial tumours. All patients had received a course of external cranial irradiation. Biochemical abnormalities of endocrine function were present in almost all of the patients. In particular, the growth hormone response to insulin induced hypoglycaemic stress was impaired in eleven out of fifteen patients. Preliminary data from a group of seven patients with intracranial tumours prior to radiotherapy are also presented. The possibility that cranial irradiation causes hypothalamic-pituitary dysfunction is discussed. The results suggest that endocrine assessment should be considered in patients who have been treated for intracranial tumours, even in the absence of direct pituitary involvement.
对17名曾接受过鞍外颅内肿瘤治疗的患者的下丘脑 - 垂体功能进行了检查。所有患者均接受过一个疗程的颅外照射。几乎所有患者都存在内分泌功能的生化异常。特别是，15名患者中有11名对胰岛素诱导的低血糖应激的生长激素反应受损。还展示了一组7名放疗前颅内肿瘤患者的初步数据。讨论了颅外照射导致下丘脑 - 垂体功能障碍的可能性。结果表明，即使在没有垂体直接受累的情况下，对于接受过颅内肿瘤治疗的患者也应考虑进行内分泌评估。
