Singer S, Singer D, Rüchel R, Mergeryan H, Schmidt U, Harms K
Department of Pediatrics, University Clinics, Göttingen, Germany.
Mycoses. 1998 May-Jun;41(5-6):223-7. doi: 10.1111/j.1439-0507.1998.tb00328.x.
Small pre-term neonates are susceptible to cutaneous aspergillosis because of their immature immune system and because of the vulnerability of their skin. In addition, the common therapy with broad-spectrum antibiotic drugs and corticoids creates a favourable milieu for fungal superinfections. We present four pre-term neonates who succumbed to cutaneous aspergillosis that subsequently developed into a systemic infection. The source of the infection proved to be contaminated latex finger stalls. Three of the four patients died. The poor prognosis for systemic aspergillosis can only be improved by an early therapy with amphotericin B, possibly in liposomal form.
由于免疫系统不成熟以及皮肤脆弱，早产新生儿易患皮肤曲霉病。此外，广谱抗生素药物和皮质类固醇的常规治疗为真菌二重感染创造了有利环境。我们报告了4例早产新生儿，他们死于皮肤曲霉病，随后发展为全身感染。感染源被证明是受污染的乳胶手指套。4例患者中有3例死亡。全身性曲霉病的不良预后只有通过早期使用两性霉素B治疗（可能采用脂质体形式）才能得到改善。
