Humerfelt S, Eide G E, Kvåle G, Gulsvik A
Department of Thoracic Medicine, University of Bergen, Norway.
Clin Physiol. 1998 Jul;18(4):387-96. doi: 10.1046/j.1365-2281.1998.00115.x.
We examined the effects from subjects, technicians and spirometers on within-session variability in successful recordings of forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in 4989 asymptomatic never-smoking men. All eligible men aged 30-46 years living in western Norway (n = 45,380) were invited to a cross-sectional community survey. Information on respiratory symptoms, smoking habits and occupational exposures was obtained from a self-administered questionnaire. Three successful FEV1 and FVC recordings were obtained in 26,368 attendants using three dry-wedge bellow spirometers operated by 10 different technicians. Within-subject standard deviation (SD) from three recordings of FEV1 and FVC was on average 102 and 106 ml, respectively, and increased with height (14 and 17 ml, respectively, per 10 cm) and body mass index (BMI) (11 and 14 ml, respectively, per 5 kg m-2). Between-subject SD of the mean of three FEV1 and FVC recordings was 591 and 754 ml, respectively, and increased in groups of increasing height (43 and 40 ml, respectively, per 10 cm). Small, but significant, differences were observed between technicians in within-subject SD and in levels of FEV1 and FVC. Homogeneity of between-subject variability, necessary for linear regression analysis, was obtained using FEV1 and FVC divided by height squared. In conclusion, within-subject variability in three successful spirometric recordings was small, but dependent on height and BMI of the subjects as well as technician performance. The observed heterogeneity in between-subject variation in FEV1 and FVC levels disappeared when each variable was divided by height squared. Novel multiple linear regression equations for FEV1/height2 and FVC/height2 were developed to be used in evaluating the effects from occupational airborne exposures in Nordic men aged 30-46 years.
我们研究了受试者、技术人员和肺活量计对4989名无症状从不吸烟男性1秒用力呼气量（FEV1）和用力肺活量（FVC）成功记录的日内变异性的影响。邀请了所有居住在挪威西部、年龄在30 - 46岁的符合条件的男性（n = 45380）参加一项横断面社区调查。通过自填问卷获取了有关呼吸道症状、吸烟习惯和职业暴露的信息。26368名参与者使用由10名不同技术人员操作的三台干式楔形风箱肺活量计成功进行了三次FEV1和FVC记录。FEV1和FVC三次记录的受试者内标准差（SD）平均分别为102和106毫升，并随身高（每10厘米分别增加14和17毫升）和体重指数（BMI）（每5 kg/m²分别增加11和14毫升）而增加。三次FEV1和FVC记录平均值的受试者间SD分别为591和754毫升，并在身高增加的组中增加（每10厘米分别增加43和40毫升）。在受试者内SD以及FEV1和FVC水平方面，技术人员之间观察到了微小但显著的差异。使用FEV1和FVC除以身高平方获得了线性回归分析所需的受试者间变异性的同质性。总之，三次成功肺活量计记录的受试者内变异性较小，但取决于受试者的身高和BMI以及技术人员的表现。当每个变量除以身高平方时，观察到的FEV1和FVC水平受试者间变异的异质性消失。开发了FEV1/身高²和FVC/身高²的新型多元线性回归方程，用于评估30 - 46岁北欧男性职业空气传播暴露的影响。
