Humerfelt S, Eide G E, Gulsvik A
Department of Thoracic Medicine, University of Bergen, Norway.
Thorax. 1998 Aug;53(8):649-55. doi: 10.1136/thx.53.8.649.
The association between occupational quartz exposure and ventilatory function was investigated in men in a general population after adjusting for other potential determinants of outcome.
All eligible men aged 30-46 years living in western Norway (n = 45,380) were invited to a cross sectional community survey. This included a self administered questionnaire (with respiratory symptoms, smoking habits and occupational exposures), spirometric recordings (using dry wedge below spirometers), and a chest radiograph (65% attendance). Measurements of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were obtained in 91% (n = 26,803) of those who participated, 26,106 of whom performed successful spirometric tests and had normal chest radiographs and remained for further analysis. Age, body mass index, and technician standardised residuals ((observed minus predicted value)/residual standard error) of maximum FEV1/height2 and FVC/height2 were used as outcome variables for adjusted lung function levels, respectively.
Occupational quartz exposure was reported by 13% (n = 3445) of those who participated in the survey, with a mean duration of seven years. Among those exposed to quartz, significant inverse linear relationships were observed between years of exposure and FEV1 level and the ratio of FEV1/FVC, independent of host characteristics. Multiple linear regression analyses showed that the difference in FEV1 associated with each year of quartz exposure was -4.3 ml (95% CI -1.1 to -7.5 ml; p = 0.01) compared with -6.9 ml (95% CI -4.7 to -9.1 ml; p < 0.01) from smoking 20 cigarettes/day for one year after adjusting for age, atopy, asthma, wheezing, marital status, and other occupational exposures.
In men aged 30-46 years with occupational quartz exposure and normal chest radiographs the duration of occupational quartz exposure was an independent predictor for spirometric airflow limitation.
在对其他可能影响结果的因素进行校正后，对普通人群中的男性职业性石英暴露与通气功能之间的关联进行了调查。
邀请所有居住在挪威西部、年龄在30 - 46岁的符合条件的男性（n = 45,380）参加一项横断面社区调查。调查内容包括一份自我填写的问卷（涉及呼吸道症状、吸烟习惯和职业暴露情况）、肺活量测定记录（使用肺活量计下方的干式楔形装置）以及胸部X光片（参与率为65%）。在参与调查的人群中，91%（n = 26,803）的人进行了一秒用力呼气容积（FEV1）和用力肺活量（FVC）的测量，其中26,106人肺活量测定测试成功、胸部X光片正常并留作进一步分析。年龄、体重指数以及最大FEV1/身高²和FVC/身高²的技术员标准化残差（（观察值减去预测值）/残差标准误）分别用作校正后肺功能水平的结果变量。
参与调查的人群中有13%（n = 3445）报告有职业性石英暴露，平均暴露时长为7年。在石英暴露人群中，观察到暴露年限与FEV1水平以及FEV1/FVC比值之间存在显著的负线性关系，且不受宿主特征影响。多元线性回归分析显示，校正年龄、特应性、哮喘、喘息、婚姻状况和其他职业暴露因素后，与每年石英暴露相关的FEV1差异为 - 4.3 ml（95% CI - 1.1至 - 7.5 ml；p = 0.01），而每天吸20支烟持续一年导致的FEV1差异为 - 6.9 ml（95% CI - 4.7至 - 9.1 ml；p < 0.01）。
在30 - 46岁有职业性石英暴露且胸部X光片正常的男性中，职业性石英暴露的时长是肺活量测定气流受限的独立预测因素。
