全球骨髓捐献者与脐血干细胞移植。

Bone Marrow Donors Worldwide and cord blood stem cell transplantation.

作者信息

van Rood J J, Schipper R F, Bakker J N, van der Zanden H G, Oudshoorn M

机构信息

Department of Immunohematology and Blood Bank, The Netherlands.

出版信息

Bone Marrow Transplant. 1998 Jul;22 Suppl 1:S19-21.

PMID:9715877

Abstract

Stem cell transplantation using cord blood donors mismatched for one or two HLA antigens can be successful. A simulation study was performed to assess the percentage of patients for whom a matched and/or a one or two antigen mismatched donor is available. Using either bone marrow donors worldwide (BMDW) (n = 925109) or the cord blood donor file in BMDW (n = 11049). As a donor source, for 97% of the Dutch patients a 0 or 1 antigen mismatched cord blood donor was available, for patients from the minority groups this percentage was 55%. These percentages compare favourably with the fraction of 0 mismatched donors found in BMDW.

摘要

使用与一个或两个HLA抗原不匹配的脐带血供体进行干细胞移植可能会成功。进行了一项模拟研究，以评估有匹配和/或一个或两个抗原不匹配供体的患者百分比。使用全球骨髓供体（BMDW）（n = 925109）或BMDW中的脐带血供体档案（n = 11049）作为供体来源。对于97%的荷兰患者，有0或1个抗原不匹配的脐带血供体可用，对于少数群体的患者，这一百分比为55%。这些百分比与在BMDW中发现的0不匹配供体的比例相比具有优势。