脐带血造血祖细胞中的细胞黏附分子
Cell adhesion molecules in cord blood hematopoietic progenitors.
作者信息
Timeus F, Crescenzio N, Marranca D, Dall'Aglio M, Fazio L, Di Marco M, Saracco P, Ricotti M, Gabutti V
机构信息
Dept of Ped Hematology/Oncology, University of Turin, Torino, Italy.
出版信息
Bone Marrow Transplant. 1998 Jul;22 Suppl 1:S61-2.
We investigated the expression of different cell adhesion molecules on cord blood (CB) and bone marrow (BM) CD34+/CD38+ and CD34+/CD38- cells. CD11a and CD62L were more expressed in CB than in BM CD34+/CD38- subset, suggesting a possible advantage in homing and engraftment. A short exposure to various cytokines increased CD62L expression only in the more differentiated CB and BM CD34+/CD38+ cells.
我们研究了不同细胞黏附分子在脐血（CB）和骨髓（BM）的CD34⁺/CD38⁺及CD34⁺/CD38⁻细胞上的表达情况。CD11a和CD62L在CB中的表达高于BM的CD34⁺/CD38⁻亚群，提示在归巢和植入方面可能具有优势。短期暴露于多种细胞因子仅使分化程度更高的CB和BM的CD34⁺/CD38⁺细胞中CD62L表达增加。
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