Armstrong J F, Hooper M L
Sir Alastair Currie CRC Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, UK.
Br J Cancer. 1998 Aug;78(4):484-5. doi: 10.1038/bjc.1998.519.
The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1-linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in inbred mice.
先前报道称，通过父系遗传突变Rb - 1等位基因的杂交小鼠垂体肿瘤发病较早，这归因于与Rb - 1相关基因的印记。在此，我们证明，正如从该机制所预测的那样，在近交系小鼠中，突变的起源亲本没有影响。
