Hooper M L
Sir Alastair Currie Cancer Research Campaign Laboratories, Department of Pathology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
EMBO J. 1998 Dec 1;17(23):6783-9. doi: 10.1093/emboj/17.23.6783.
Tumour suppressor genes prevent cancer development. They can be identified by studying humans, but a full understanding of the mechanisms of their action requires the production of animal models. Mice with mutations in tumour suppressor genes can be produced by gene targeting. The phenotypic consequences of tumour suppressor gene mutations in mice and humans show parallels and contrasts, and both can contribute to the elucidation of disease processes.
肿瘤抑制基因可预防癌症的发生。通过对人类的研究可以识别它们，但要全面了解其作用机制则需要建立动物模型。通过基因靶向技术可以培育出肿瘤抑制基因发生突变的小鼠。小鼠和人类肿瘤抑制基因突变的表型后果既有相似之处，也有不同之处，二者都有助于阐明疾病的发生过程。
