一名年轻患者因凝血酶原20210 G→A突变发生急性心肌梗死，双侧冠状动脉内有大量血栓形成。
Acute myocardial infarction with large bilateral intracoronary thrombi in a young patient with the prothrombin 20210 G-->A mutation.
作者信息
de Winter R J, Middeldorp S, Gaffar S, Koch K T, Piek J J, Levi M, Reitsma P H
机构信息
Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands.
出版信息
Cathet Cardiovasc Diagn. 1998 Aug;44(4):427-30. doi: 10.1002/(sici)1097-0304(199808)44:4<427::aid-ccd15>3.0.co;2-f.
Abstract
A genetic variation in the 3'-UT region of the prothrombin gene, a G to A mutation at nucleotide 20210, has been associated recently with increased risk of acute myocardial infarction. We describe a case of a young patient carrying the mutation, with an AMI caused by large bilateral intracoronary thrombi, that underwent direct PTCA.
摘要
凝血酶原基因3'-非翻译区的一种基因变异，即核苷酸20210处的G到A突变，最近被发现与急性心肌梗死风险增加有关。我们描述了一例携带该突变的年轻患者，其因双侧冠状动脉内大量血栓形成导致急性心肌梗死，并接受了直接经皮冠状动脉腔内血管成形术（PTCA）。
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