Kauma H, Ikäheimo M, Savolainen M J, Kiema T R, Rantala A O, Lilja M, Reunanen A, Kesäniemi Y A
Department of Internal Medicine, University of Oulu, Finland.
Eur Heart J. 1998 Jul;19(7):1109-17. doi: 10.1053/euhj.1998.0155.
Variants of renin-angiotensin system genes are shown to be associated with cardiovascular pathology. The association between renin-angiotensin system genes and left ventricular mass was investigated in a population-based case-control study.
The association between echocardiographic left ventricular mass and both insertion/deletion polymorphism of the angiotensin-converting enzyme gene and the methionine-threonine variant at position 235 of the angiotensinogen gene was studied in a random cohort of 430 hypertensive and 426 control subjects. No differences in the adjusted left ventricular mass values between the different genotypes were seen among either the hypertensive or the control subjects, whether men or women, or in the subgroups of normotensive or physically active subjects. Gene variation had no statistically significant synergistic effect on left ventricular mass values. In control women, the deletion allele of the angiotensin-converting enzyme gene was associated with an increased risk of left ventricular hypertrophy. However, this finding was based on a small number of women with left ventricular hypertrophy and should be interpreted with caution.
Variations in renin-angiotensin system genes had no major effect on left ventricular mass in this middle-aged population-based cohort of hypertensives and control subjects.
肾素 - 血管紧张素系统基因变异与心血管病变相关。在一项基于人群的病例对照研究中，对肾素 - 血管紧张素系统基因与左心室质量之间的关联进行了调查。
在一个由430名高血压患者和426名对照者组成的随机队列中，研究了超声心动图测量的左心室质量与血管紧张素转换酶基因的插入/缺失多态性以及血管紧张素原基因第235位甲硫氨酸 - 苏氨酸变异之间的关联。无论是高血压患者还是对照者，无论男性还是女性，或者在血压正常或身体活跃的亚组中，不同基因型之间调整后的左心室质量值均无差异。基因变异对左心室质量值没有统计学上的显著协同作用。在对照女性中，血管紧张素转换酶基因的缺失等位基因与左心室肥厚风险增加相关。然而，这一发现基于少数左心室肥厚的女性，应谨慎解读。
在这个基于中年人群的高血压患者和对照者队列中，肾素 - 血管紧张素系统基因变异对左心室质量没有重大影响。
