高剂量促性腺激素用于体外受精的超排卵：是否有效？
Superovulation with a high gonadotropin dose for in vitro fertilization: is it effective?
作者信息
Lashen H, Ledger W, López Bernal A, Evans B, Barlow D
机构信息
Academic Department, Birmingham University, Birmingham Women's Hospital, Edgbaston, U.K.
出版信息
J Assist Reprod Genet. 1998 Aug;15(7):438-43. doi: 10.1007/BF02744938.
PURPOSE
Our purpose was to investigate the effect on the ovarian response of increasing the gonadotropin dose.
METHODS
We analyzed retrospectively the in vitro fertilization data for patients who had two cycles of treatment, with a higher dose in cycle 2. The patients were stratified according to age, ovarian response, and gonadotropin dose in the first cycle. The main outcome measure was the number of follicles, eggs, and embryos and the peak estradiol (E2) level.
RESULTS
The study included 244 patients. Patients in both age groups (n = 118, < or = 33 years; n = 126, > 33 years), low (n = 66) and intermediate (n = 145) responders, and patients who received < 225 IU follicle-stimulating hormone (n = 175) in cycle 1 had a better response in cycle 2. However, the high responders (n = 33) and those who received 225 or 300 IU follicle-stimulating hormone (n = 69) in cycle 1 showed a similar response in both cycles, except for a significantly higher E2 level in cycle 2.
CONCLUSIONS
Our results indicate that exceeding a daily dose of 300 IU is unrewarding.
目的
我们的目的是研究增加促性腺激素剂量对卵巢反应的影响。
方法
我们回顾性分析了接受两个周期治疗的患者的体外受精数据，第二周期使用更高剂量。根据年龄、卵巢反应和第一周期的促性腺激素剂量对患者进行分层。主要观察指标是卵泡、卵子和胚胎的数量以及雌二醇（E2）峰值水平。
结果
该研究纳入了244例患者。两个年龄组（n = 118，≤33岁；n = 126，> 33岁）、低反应者（n = 66）和中等反应者（n = 145）以及第一周期接受<225 IU促卵泡激素（n = 175）的患者在第二周期有更好的反应。然而，高反应者（n = 33）和第一周期接受225或300 IU促卵泡激素（n = 69）的患者在两个周期中的反应相似，只是第二周期的E2水平显著更高。
结论
我们的结果表明，每日剂量超过300 IU并无益处。
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