受精卵移植与胚胎移植：一项前瞻性随机多中心试验。
Zygote versus embryo transfer: a prospective randomized multicenter trial.
作者信息
Dale Brian, Fiorentino Agnese, de Simone Maria Laura, di Matteo Loredana, di Frega Antonio Scotto, Wilding Martin, Fehr Peter, Bassan Emma, Lo Giudice Cristoforo, Maselli Antonio, Cappiello Fulvio, Zullo Fulvio
机构信息
Center for Reproductive Biology, Clinica Villa Del Sole, Naples, Italy.
出版信息
J Assist Reprod Genet. 2002 Oct;19(10):456-61. doi: 10.1023/a:1020354318164.
PURPOSE
To determine the efficiency of transferring human zygotes as opposed to human day 2 or 3 embryos.
METHODS
A prospective, randomized, Multicenter trial. Patients were randomized into zygote or embryo transfer. Patients were prepared for oocyte retrieval using standardized protocols. Oocyte retrieval was performed under general anesthesia. Oocytes and spermatozoa were treated using standard laboratory techniques. All protocols were coordinated by the coordinating center.
RESULTS
A total of 386 patients were included in the trial. Pregnancy rates were 36.5% after zygote transfer and 42% after embryo transfer. Implantation rates were equivalent (17%) in both groups.
CONCLUSIONS
No general difference was observed for zygote or embryo transfer. The results suggest that zygote transfer is a valid alternative to embryo transfer.
目的
确定与人类第2天或第3天胚胎相比，人类受精卵移植的效率。
方法
一项前瞻性、随机、多中心试验。患者被随机分为受精卵移植组或胚胎移植组。使用标准化方案为患者准备取卵。取卵在全身麻醉下进行。卵母细胞和精子使用标准实验室技术处理。所有方案均由协调中心协调。
结果
共有386名患者纳入试验。受精卵移植后的妊娠率为36.5%，胚胎移植后的妊娠率为42%。两组的着床率相当（17%）。
结论
受精卵移植和胚胎移植未观察到总体差异。结果表明，受精卵移植是胚胎移植的有效替代方法。
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