真菌中的细胞色素P450
Cytochromes P450 in fungi.
作者信息
Vanden Bossche H, Koymans L
机构信息
Department of Anti-infectives Research, Janssen Research Foundation, Beerse, Belgium.
出版信息
Mycoses. 1998;41 Suppl 1:32-8. doi: 10.1111/j.1439-0507.1998.tb00581.x.
Abstract
The article gives an overview on the history of the discovery of P450 cytochromes and on their occurrence in nature, especially on their interactions with metabolic pathways in fungi. The significance of the P450 cytochromes in the ergosterol synthesis as well as in the inhibitory mechanisms caused by imidazole and triazole antimycotics is described in detail.
摘要
本文概述了细胞色素P450的发现历史及其在自然界中的存在情况，尤其阐述了它们与真菌代谢途径的相互作用。详细描述了细胞色素P450在麦角固醇合成中的意义，以及咪唑和三唑类抗真菌药物引起的抑制机制。
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