Slatkin M, Wiehe T
Department of Integrative Biology, University of California, Berkeley 94720-3140, USA.
Genet Res. 1998 Apr;71(2):155-60. doi: 10.1017/s001667239800319x.
The problem of genetic hitch-hiking in a geographically subdivided population is analysed under the assumption that migration rates among populations are relatively small compared with the selection coefficient for a newly arising advantageous allele. The approximate method used in the paper is valid when the number of emigrants per generation (Nm) is less than one. The approximate analysis shows that hitch-hiking can result in substantial differences among populations in the frequencies of neutral alleles closely linked to the advantageous allele. Thus, in cases for which genetic hitch-hiking is thought to be responsible for low levels of genetic variability in regions of the genome with restricted crossing over, it might be possible to find confirmatory evidence for that hypothesis by finding unusual patterns of geographic differentiation in the same regions of the genome.
在地理上细分的种群中，基因搭便车问题在这样的假设下进行了分析：与新出现的有利等位基因的选择系数相比，种群间的迁移率相对较小。本文使用的近似方法在每代移民数量（Nm）小于1时有效。近似分析表明，基因搭便车会导致与有利等位基因紧密连锁的中性等位基因在种群频率上产生显著差异。因此，在认为基因搭便车是基因组中重组受限区域遗传变异性低的原因的情况下，有可能通过在基因组相同区域发现异常的地理分化模式来找到该假设的证实证据。
