Chander R, Singh K, Visen P K, Kapoor N K, Dhawan B N
Biochemistry Division, Central Drug Research Institute, Lucknow, India.
Indian J Exp Biol. 1998 Apr;36(4):371-4.
Picroliv, an iridoid glycoside mixture from the root and rhizome of Picrorhiza kurrooa, at the dose of 6 mg/kg p.o. for two weeks provided significant protection against the generation of lipid peroxidation products in serum beta-lipoproteins of P. berghei infected M. coucha. Incubation of normal rat hepatocytes with very low density lipoprotein or low density lipoprotein isolated from infected animals caused significant generation of lipid peroxides followed by a decrease in the viability of these cells, however these effects were partially reversed with the lipoproteins from infected and picroliv treated groups. High density lipoprotein from infected animals was not toxic to hepatocytes in vitro.
苦味叶下珠素，一种从胡黄连的根和根茎中提取的环烯醚萜苷混合物，以6毫克/千克的口服剂量给药两周，可显著保护感染伯氏疟原虫的沙鼠血清β-脂蛋白中脂质过氧化产物的生成。用从感染动物中分离出的极低密度脂蛋白或低密度脂蛋白孵育正常大鼠肝细胞，会导致脂质过氧化物的大量生成，随后这些细胞的活力下降，然而，感染组和苦味叶下珠素治疗组的脂蛋白可部分逆转这些效应。感染动物的高密度脂蛋白在体外对肝细胞无毒。
